ISSN:
1432-0533
Keywords:
Key words Alzheimer’s disease
;
Cerebral cortex
;
Neuronal loss
;
Pick’s disease
;
Presenilin-1
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Recent studies have reported that neuronal populations expressing low levels of presenilin-1 (PS-1) display increased vulnerability in late-onset sporadic Alzheimer’s disease (AD). To examine whether this phenomenon also occurs in other neurodegenerative diseases, we performed a quantitative immunocytochemical study of PS-1 distribution in the cerebral cortex of Pick’s disease (PiD) cases and non-demented individuals. In PiD cases, the percentage of PS-1-containing, Pick body (PB)-free neurons was significantly elevated only in cortical areas showing neuronal loss. In these areas, PS-1 levels, measured by immunoblotting, were often higher in PiD compared to non-demented cases. Moreover, PS-1 immunoreactivity was significantly reduced in PB-containing neurons. These data suggest that as previously shown in AD, low cellular expression of PS-1 may be associated with increased neuronal loss and cellular degeneration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004010051114
