ISSN:
1432-0533
Keywords:
Key words Neuropathy
;
Docetaxel
;
Paclitaxel
;
Neurotoxicity
;
Peripheral nerves
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004010051132