ISSN:
1432-069X
Keywords:
TNFα
;
Immunohistochemistry
;
Immunoelectron microscopy
;
Epidermis
;
Sebaceous glands
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The presence, distribution and cellular localization of tumour necrosis factor-alpha (TNFα) were investigated in normal human and murine epidermis using immunohistological and immunoelectron microscopic methods with monoclonal and polyclonal antibodies. The immunostaining revealed an intercellular plasma membrane and cytoplasmic labelling of the epidermal keratinocytes, but no labelling of Langerhans cells, melanocytes and Merkel cells. Large amounts of TNFα were regularly found in the sebaceous glands. These findings demonstrate that epidermal keratinocytes and especially sebocytes produce and release TNFα and that this keratinocytederived cytokine may be important for the structural and functional homeostasis of normal epidermis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00372709
