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Immunoelectron microscopic study of the conjunctiva in cicatricial pemphigoid (1999)

Robin, H. ; Hoang-Xuan, T. ; Prisant, O. ; [et al.]

Springer

Graefe's archive for clinical and experimental ophthalmology 237 (1999), S. 39-44

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ISSN: 1435-702X

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract · Background: Immune deposits can be found on the conjunctival basement membrane zone of patients affected by cicatricial pemphigoid using immunofluorescence technique. The purpose of this study was to perform direct immunoelectron microscopy on the conjunctiva of patients with scarring conjunctivitis associated with cicatricial pemphigoid · Methods: Conjunctival and skin biopsies were performed in six patients who presented with presumed autoimmune cicatrizing conjunctivitis associated with cicatricial pemphigoid. Specimens were processed for direct immunofluorescence and direct immunoelectron microscopy. · Results: Direct immunofluorescence was positive in all skin samples and in three of six conjunctival samples. Direct immunoelectron microscopy showed immune deposits in the lamina lucida and the lamina densa of all skin and conjunctival samples. · Conclusions: Direct immunoelectron microscopy can be performed on the conjunctiva. It shows the precise localization of cicatricial pemphigoid target antigens within the conjunctival basement membrane zone.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004170050192

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