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Digitale Medien

Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease (1994)

Horwood, N. ; Davies, D. C.

Springer

Virchows Archiv 425 (1994), S. 69-72

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Details

ISSN: 1432-2307

Schlagwort(e): GLUT-1 Glucose transporter protein ; Immunohistochemistry ; Microvessel endothelium ; Hippocampus ; Alzheimer's disease

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Changes in cerebral microvessel ultrastructure have been reported to occur in Alzheimer's disease (AD). In order to investigate whether these changes are associated with compromised blood-brain transport mechanisms, hippocampal formation sections from AD and age-matched normal brains were immunolabelled with an antibody to the GLUT-1 glucose transporter protein. GLUT-1 immunolabelling of microvessel endothelium was significantly reduced in the AD compared to normal hippocampal formation. Thus, AD is associated with a reduction in cerebral microvessel endothelium glucose transporter content, which may result in decreased glucose availability to the brain.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00193951

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