ISSN:
1432-0568
Keywords:
Carotid sinus
;
Baroreceptors
;
Innervation
;
Substance P
;
Neurotensin
;
Neuropeptides
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The carotid sinus of the guinea pig was analysed immunohistochemically for the occurrence of neuropeptides. Immunoreactivity (IR) for neurotensin (NT) and substance P (SP) is distributed in two different populations of nerve endings and varicosities. NT-IR fibers penetrate deeply into the tunica media of the elastic segment of the carotid sinus and form the large, branched lanceolate nerve terminals. Electron-microscopic investigations have revealed that the NT-IR varicosities correspond to the large afferent baroreceptor endings containing abundant mitochondria. SP-IR fibers are located mainly at the mediaadventitial border. They seem to be correlated to dense-core, vesiclecontaining varicosities identified in the electron microscope. Therefore, these fibers may constitute afferent and efferent perivascular plexus regulating the vascular tone of the carotid sinus wall.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315672
