ISSN:
1433-8580
Keywords:
Glucosidase inhibitor
;
BAY g 5421
;
Blood glucose
;
Serum insulin
;
Serum triglycerides
;
Acarbose
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In blind studies the effects of a newα-glucosidase inhibitor (BAY g 5421) were tested in normal weight and overweight male volunteers after oral application of 75, 150, or 300 mg of BAY g 5421 or placebo per os before three standardized main meals of one day. Before and three hours after each meal blood glucose, serum insulin, and serum triglyceride levels were determined. In addition, safety studies were performed. BAY g 5421 induced a statistically significant, in part dose-dependent inhibition of the postprandial increase of blood glucose- and serum insulin levels. The reduction of the postprandial increase of serum triglyceride levels was variable. Routine blood chemistry and hematology tests have revealed no adverse side effects; but the application of the drug was frequently associated with intestinal effects, such as flatulence and diarrhea, which were substrate (carbohydrate) and, in part, dose-dependent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01851236
