ISSN:
1432-1955
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Description / Table of Contents:
Zusammenfassung Ein Versuch an 26 genetisch nicht einheitlichen Läuferschweinen, eine Immunität gegen E. scabra durch Lymphozyten aus den regionären Lymphknoten zu übertragen, mißlang. Dagegen konnte in 3 Versuchsreihen mit 160 isohistokompatiblen E3/Han (F 38) Ratten eine Immunität gegen E. nieschulzi adoptiv übertragen werden. Durch intraperitoneale Injektion der Lymphozyten aus den Mesenteriallymphknoten, nicht jedoch der Zellen aus den Peyerschen Platten, gelang es, in allen 3 Reihen die Oozystenausscheidung nach einer Testinfektion hochsignifikant (p〈0,01) zu reduzieren.
Notes:
Summary An attempt to transfer immunity to a pure strain of E. scabra by transferring lymphocytes from regional lymphnodes from immune to non-immune randomly bred weaner pigs gave negative results. In three additional experiments we used 160 highly inbred E3/Han (F 38) rats, which would accept skin transplants from each other. We eventually succeeded in adoptively transferring immunity to a pure strain of E. nieschulzi by intraperitoneal injection of lymphocytes. Lymphocytes, both from immune and non-immune animals, were transferred, separately, both from mesenteric lymphnodes and from Peyer's patches. The lymphocytes obtained from five or six donors were added together and injected into one recipient. One, two, or three days after lymphocyte transfer the recipients were given a dose of 1 000 or 10 000 sporulated oocysts. A highly significant reduction in oocyst output was obtained — on an average from 82, 56, and 172 to 23, 26, and 69 million — but only by transferring lymphocytes from the mesenteric lymph nodes of immune animals. Lymphocytes from the Peyer's patches were not able to transfer immunity. These experiments definitely showed a lymphocyte-mediated cellular basis of immunity to coccidia, but our findings do not exclude the existence of some additional immune mechanisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00348562
