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A new HaeIII polymorphism at the D21S13 locus (1990)

Pulst, S. -M. ; Korenberg, J. R. ; Ren, M. ; [et al.]

Springer

Human genetics 〈Berlin〉 85 (1990), S. 671-671

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ISSN: 1432-1203

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary DNA markers in the pericentromeric region of human chromosome 21 have shown linkage to a gene for Familial Alzheimer disease (FAD; St. George Hyslop et al. 1987). The limited informativeness of probes for the loci D21S13 and D21S16 have hindered precise mapping of the FAD locus and analysis of non-allelic heterogeneity in FAD (Schellenberg et al. 1988; St. George-Hyslop et al. 1987). We recently described a new EcoRII polymorphism at the D21S13 locus that was very informative in a large FAD pedigree (Pulst et al. 1990a, b). We now report another polymorphism for the D21S13 locus that further increases the informativeness of this locus.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00193597

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