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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 21 (2000), S. S913 
    ISSN: 1590-3478
    Keywords: Key words Amyotrophic lateral sclerosis ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pathways leading to motorneuron degeneration in amyotrophic lateral sclerosis (ALS) are complex. Excitotoxicity, oxidative damage and, maybe, abnormal aggregation of neurofilaments are key events on which therapeutical strategies can be designed. This paper reviews current knowledge on these strategies. Even though we should be aware that appropriate management of disease symptoms remains the most effective therapeutical intervention, understanding the pathophysiology of ALS is essential for developing new therapies.
    Type of Medium: Electronic Resource
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