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Hard tissue biochemistry: A comparison of fresh-frozen and formalin-fixed tissue samples (1982)

Boskey, A. L. ; Cohen, M. L. ; Bullough, P. G.

Springer

Calcified tissue international 34 (1982), S. 328-331

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ISSN: 1432-0827

Keywords: Formalin fixation ; Bone tissue ; Hydroxyproline ; Uronate ; Lipid

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Summary Formalin fixation of hard tissues alters the levels of some, but not all, of the parameters routinely measured by bone researchers. Although mineral parameters (ash weight, particle size (β 1/2 002) and Ca/PO4 ratio) and lipid parameters (total lipid content and composition, extractability, and Ca-acidic phospholipid phosphate content) are not affected by formalin fixation, the uronate and DNA contents are reduced in formalin-fixed bone while hydroxyproline content is elevated.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02411262

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