ISSN:
1432-1424
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Summary It has been found that then-alkyl bromides are capable of inducing the fusion of unilamellar liposomes. These compounds can bring about fusion of liposomes composed of either pure phosphatidylcholine or phosphatidylcholine + phosphatidic acid. Fusion of unilamellar liposomes gives rise to multilamellar structures, the morphology of which has been examined by negative staining and freeze-fracture techniques. It has been shown by microelectrophoresis that then-alkyl bromides have no effect on the surface charge of liposomes, and fusion has been further characterized by use of light scattering and differential scanning calorimetry, the latter indicating that true mixing of the fatty acyl chains occurs upon fusion. Finally, fusion occurs atn-alkyl bromide levels below that required to saturate the aqueous phase of the system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01926370
