ISSN:
1432-1432
Keywords:
Invertebrate
;
Collagen
;
Gene evolution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract We have completed the analysis of a genomic clone, G238, that contains most of the coding region of the sponge COLF1 fibrillar collagen gene. The main triple helical domain is encoded by 31 exons. Except for the 5′ junction exon and the two last 3′ exons (126 and 18 base pairs), all these exons are related to a 54-bp unit and begin with an intact glycine codon. A good correlation can be made between this sponge gene and a vertebrate fibrillar collagen gene, revealing the high conservation of the members of this family during evolution. The reconstitution of an ancestral collagen gene can be made by considering all the exon/intron junctions of these genes. We suggest that such an ancestral gene arose from multiple duplications of a 54-bp exon and a (54 + 45)-bp module.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00175502
