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The stumbler mutation maps to proximal mouse Chromosome 2 (1994)

Frankel, W. N. ; Sweet, H. O. ; Davisson, M. T.

Springer

Mammalian genome 5 (1994), S. 659-662

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ISSN: 1432-1777

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The cerebellar mouse mutation stumbler (stu) was mapped to proximal Chromosome (Chr) 2 with a recently developed polymerase chain reaction assay for endogenous retroviruses that vary between mouse strains. The stu locus resides between the markers D2Mit5 and D2Mit7. A number of developmentally or neurologically relevant candidate genes map in this region, including Bmi1, Dbh, Grin1, Notch1, Pax8, Rxra, and Spna2. Knowing the chromosomal localization of stu should simplify maintenance of the stumbler mouse stock and also enable analysis of the cerebellar defect in presymptomatic individuals.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00426071

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