ISSN:
1435-1463
Keywords:
Serotonergic
;
adrenergic
;
receptors
;
alcohol-prefering rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Serotonergic and adrenergic receptors in brain areas of the alcohol-preferring P and alcohol-nonpreferring NP rats were compared by radioligand-binding assays. Binding of3H-serotonin (3H-5HT) to 5HT-1 receptors in membranes of cerebral cortex and hippocampus was significantly higher in density (B max values) and affinity (Kd values) in the P than in the NP rats, whereas B max values in membranes from the brain stem of the P rats were lower than those of the NP rats. No significant difference between the P and NP lines was observed when the binding of3H-ketanserin to 5HT-2 receptors and of3H-WB4101,3H-clonidine and3H-dihydoalprenolol to α-1, α-2 and β-adrenergic receptors was compared. The increase of3H-5HT binding probably indicates up-regulation or supersensitivity of 5HT-1 receptors as a compensatory mechanism to the lower levels of 5HT in brain areas of the P rats (Murphy, et al., 1982).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01245714
