ISSN:
1435-1463
Keywords:
Competitive NMDA-antagonists (SDZ EAA-494, CGP 37849)
;
dopamine agonists (CI 201-678, SDZ 205-152)
;
glutamate
;
dopamine
;
locomotion
;
mouse
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The competitive NMDA-antagonists SDZ EAA-494 and CGP 37849 and the mixed D-1/D-2 dopamine agonists CI 201-678 and SDZ 205-152 reverse akinesia in monoamine-depleted mice in a dose dependent manner. Combination of threshold doses of NMDA-antagonists with dopamine agonists markedly enhances anti-akinetic effects. CI 201-678 which in addition to D-1 and D-2 receptors stimulates α-2 receptors produces a stronger effect than SDZ 205-152 which is devoid of α-2 agonist activity. The results indicate that concomitant blockade of NMDA-receptors and activation of dopamine receptors results in synergistic or at least additive motor stimulatory effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01244971
