ISSN:
1435-1463
Keywords:
Pressure
;
A23187
;
ionophore
;
HPNS
;
GABA release
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Guinea pig cerebrocortical synaptosome preparations were used to study the effect of compression to 62 ATA on45Ca2+ uptake and [3H]GABA release using a calcium ionophore A23187, which bypasses the voltage-sensitive calcium channel. Pressure was found to exert a suppressive effect on the A 23187-induced release of [3H]GABA, while having no significant effect on A 23187-stimulated45Ca2+ uptake. On the other hand, both depolarization-induced45Ca2+ uptake and [3H]GABA release were inhibited by pressure exposure. These results suggest that pressure may suppress GABA release by affecting pre-synaptic events subsequent to calcium influx.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01250371
