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Effect of estradiol and progesterone on muscle weight and acetylcholine receptors in “myasthenic” rats (1992)

Kempen, G. Th. H. ; Molenaar, P. C.

Springer

Journal of neural transmission 87 (1992), S. 193-197

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ISSN: 1435-1463

Keywords: Acetylcholine receptors ; estradiol ; myasthenia gravis ; neuromuscular junction ; progesterone

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Clinical evidence suggests that endocrinal factors are involved in fluctuations of the symptoms of women with myasthenia gravis. We studied the effect of estradiol and progesterone in an animal model for myasthenia gravis in rats. Although it was found that the mass of muscles was dependent on sex, and in female rats affected by estradiol, the number of acetylcholine receptors in these muscles was independent of sex and hormone administration. Sex hormones failed to influence the severity of muscle weakness in myasthenic rats.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01245365

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