ISSN:
1432-8798
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Of four strains of TGE virus tested, the Purdue strain could be propagated serially and produced a cytopathic effect (CPE) in primary monolayer cultures of adult and fetal pig kidney cells, pig thyroid cells, and pig salivary gland cells. In kidney and salivary gland cell cultures, a distinct CPE was observed only after several passages. In thyroid cell cultures, a marked CPE was evident in the first passage. High cell passage virus caused the rapid and complete destruction of and produced plaques regularly in pig thyroid cell cultures, while plaque production in pig kidney cell cultures was irregular. The CPE was accompanied by acid production. New infectious virus appeared in fetal pig kidney cells less than 5 hours after infection. TGE virus was found to be ether, acid, and heat labile. Serial passage in fetal pig kidney cells led to a considerable attenuation of TGE virus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01241952
