ISSN:
1434-4475
Keywords:
Pleuromutilin
;
Inversion of configuration
;
Reversible retro-en-cleavage
;
Simmons-Smith-reaction
;
Type I-“metallo-en”-reaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The reaction of pleuromutilin-22-0-tosylat(2) withEtZnI afforded a mixture of the 12-epimeric compounds2 and3. A reversible retro-en-reaction of the homoallylic system is discussed as a possible mechanistic pathway. The structure assignment is based on1H- and13C-NMR spectroscopic data.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00811277