ISSN:
1438-2199
Keywords:
Amino acids
;
Unusual amino acids
;
Aspartic acidβ-semialdehyde
;
Aspartaldehyde
;
2-Amino-4-oxobutyric acid
;
Enantioselective synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Strategies for the synthesis of optically active aspartaldehyde derivatives are reviewed. Most of them are using the chiral pool: allylglycine or naturally occurring homoserine, aspartic acid or methionme and side chain modifications. This will be developed in the first part. Some other original routes are also displayed in the second part. Different aspects of each strategy are discussed: the nature and number of steps, the problem of protecting groups, the price and availability of starting materials. Some synthetic applications of such interesting chiral synthons are shown in the last part.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01388171
