ISSN:
1438-2199
Keywords:
Keywords: Amino acids
;
NMDA
;
Channel blockers
;
Memantine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary. The previous overviews provided the basis for better therapeutic efficacy/tolerability of low to moderate affinity NMDA channel blockers. This prediction finds support in in vitro studies comparing protective and plasticity impairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. But can it be confirmed in the in vivo situation?
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007260070045