ISSN:
1432-1459
Keywords:
Diabetic neuropathy
;
Aldose reductase inhibition
;
Sorbinil
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A randomized placebo-controlled double-blind cross-over study was conducted in order to examine the effect of an aldose reductase inhibitor, sorbinil (100 mg daily for 4 weeks), on red cell sorbitol concentration and clinical and electrophysiological parameters of diabetic neuropathy. A total of 31 diabetic patients with either clinically or electrophysiologically verified diabetic neuropathy were studied. Red cell sorbitol levels decreased significantly to the levels reported in non-diabetic subjects, but there were no significant changes in symptoms, signs, vibration perception thresholds or nerve conduction variables. One patient had transient skin rash, fever, myalgia and leucopenia, but no other significant adverse effects were found.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314428