ISSN:
1432-1459
Keywords:
Parkinson's disease
;
Depression
;
Human cerebrospinal fluid
;
5-Hydroxyindoleacetic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Depression is frequently encountered in Parkinson's disease and was seen to occur in 14 of 26 patients studied. The levels of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin (5-HT), in CSF samples of the patients were significantly lower than in those of controls. However, within the group of patients the levels of 5-HIAA in CSF samples were significantly lower in the depressive subgroup compared with the non-depressive patients. Moreover, no correlation was recorded between motor disability and depression. The results indicate that disturbed 5-HT metabolism may possibly play a role in Parkinson's disease as a predisposing factor in the development of depression.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314109
