ISSN:
1432-1459
Keywords:
Key wordsl-Threo-3
;
4-dihydroxyphenylserine
;
Orthostatic hypotension
;
Multiple system
;
atrophy
;
Plasma renin activity
;
Angiotension II
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We evaluated the effect of l-threo-3,4-dihydroxyphenylserine (l-threo-DOPS) on the response of blood pressure and vasoactive factors during head-up tilt in patients with multiple system atrophy (MSA). After the daily oral administration of 300 mg l-threo-DOPS for 2 weeks we observed a significant reduction in the decline of systolic blood pressure during 60° head-up-tilt. In concordance with this result, we detected significant increases in postural changes in plasma renin activity and angiotensin II following l-threo-DOPS treatment. The enhanced responses of these vasoactive mediators by l-threo-DOPS during head-up tilt may contribute to the improvement in orthostatic hypotension in patients with MSA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004150050333