ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Optical resolution
;
Polymeric adsorbents
;
Penicillin sulfoxide
;
Copolymerization
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A methacrylamide carrying penicillin sulfoxide skeleton, benzyl 1-oxo-6-methacrylaminopenicillanate, was copolymerized with methyl methacrylate. The optical resolution efficiency of the columns comprising the obtained copolymers was investigated using a high-performance liquid chromatography system. A copolymer incorporated by 27mol% of methyl methacrylate showed higher chirality recognition capability than the homopolymer, which suggests that the introduction of methyl methacrylate contributes to enriching desired penicillin sulfoxide alignment (i. e., tracticity) along the polymer main chain. An estimated penicillin monomer's number-average sequence length in the copolymer was 2.7.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02261072
