ISSN:
1600-5759
Source:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Topics:
Chemistry and Pharmacology
,
Geosciences
,
Physics
Notes:
The structural information gained from the study of the chiral building block (R)-(−)-4-(3,4-dichlorophenyl)-4-(2-pyridyl)butanoic acid–L-(−)-ephedrine [methyl(1-hydroxy-1-phenylprop-2-yl)ammonium 4-(3,4-dichlorophenyl)-4-(2-pyridyl)butanoate], C10H16NO+·C15H12Cl2NO2−, can be used to deduce the absolute configuration of highly potent arpromidine-type histamine H2 receptor agonists, as the chiral butanoic acid can be converted to (R)-(−)-3-(3,4-dichlorophenyl)-3-(2-pyridyl)propylamine and to the corresponding R-configured arpromidine analogue.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1107/S0108270199014699