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(R/S)-3-(3-Methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate (2001)

Dupont, Léon ; De Tullio, Pascal ; Tinant, Bernard ; [et al.]

Copenhagen : International Union of Crystallography (IUCr)

Acta crystallographica 57 (2001), S. o1050-o1051

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ISSN: 1600-5368

Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001

Topics: Chemistry and Pharmacology , Geosciences , Physics

Notes: The crystal structure of the title compound, C11H16N4O2S·H2O, a pancreatic B-cell selective KATP channel opener, reveals that that the N-alkylsulfonylguanidine moiety of the drug containing the two guanidine NH groups in the same spatial orientation (in parallel) is closely related to the N-alkylcyanoguanidine moiety of pinacidil in the solid state. The results confirm that the title drug may be considered as a hybrid compound between pinacidil and diazoxide. The crystal packing involves four hydrogen bonds which link the drug and water molecules.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1107/S1600536801016622

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