ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Transplantation surgeries of autologous bone require a second surgery with inherent risks. To avoid these risks, we developed a multi porous implant of hydroxyapatite/collagen composite with desirable biophysical properties (flexibility, elasticity and compression resistance) for use with OP-1 as a graft implant. In this study, we tested the efficacy of this multi porous implant as OP-1carrier using rabbit posterolateral lumbar fusion model (PLF). PLFs were performed in the following 4 groups of 8 New Zealand white rabbits each: autograft, HAp/Col alone, HAp/Col plus 0.3 mg OP-1, and HAp/Col plus 1.2 mg OP-1. At 5 weeks, fusion masses were analyzed by radiographic and biomechanical tests. Implants consisting of HAp/Col plus OP-1 were more effective than autologous bone in promoting spinal fusion. Low dose and high dose OP-1 wereequally effective
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.309-311.977.pdf