ISSN:
1662-8985
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Drug dosage delivered by drug-coated microneedle is dependent on needle insertionbehavior. The insertion length and gripping force at varied insertion speeds are determinedquantitatively using a precision test frame. The ratio of inserted depth to pressed depth was foundto rise asymptotically to a plateau, but decreased rapidly to zero insertion when the needles arepressed less than 1000 microns deep for both silicone rubber and porcine skin. No insertion wasobserved when the needles are pressed less than 200 microns. The gripping force exerted onto theinserted needle by the skin decreased by 0.1N per mm of needle diameter and insertion depth. Theshort insertion depth and low force suggest that drug delivery using short 300 micron microneedleswould be tenuous. High insertion speeds can help to improve drug delivery, but the improvement islimited to large needles since the results from this study showed that insertions become speedindependentwhen the needle diameter is less than 130 microns
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.1442.pdf
