Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of cutaneous pathology
14 (1987), S. 0
ISSN:
1600-0560
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Macromelanosomes in a spindle and epithelioid cell nevus, which occurred in the electron beam-damaged skin of a woman with mycosis fungoides, were ultrastructurally investigated. The melanosomes in the spindle and epithelioid cells were varied in size but uniformly spherical in shape and composed of a core and cortex structure. Electron-lucent bodies were observed in the small melanosomes as well as in the macromelanosomes. Positive dopaoxidase reaction was revealed on the cortex of these melanosomes and partly on their electron-lucent bodies. The electron-lucent bodies were not vesicular structures but were aggregates of filamentous elements, which had a continuity with fibrous structures in the melanosome cortex. It is concluded that the electron-lucent bodies may be one of the matrices of melanization. Anomalously large accumulations of these bodies and concentrical melanization seem to lead to the formation of macromelanosomes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0560.1987.tb00128.x
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