ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. As an adrenalectomized sheep becomes progressively more Na+ deplete, its salivary electrolyte secretion becomes increasingly sensitive to exogenous aldosterone administration.2. Alteration in mineralocorticoid receptor affinity or concentration is a possible mechanism whereby this sensitivity could be expressed at a molecular level.3. Binding sites with a high affinity for aldosterone (Kd 37°C∼5 × 10-10 M) have been demonstrated in sheep kidney and parotid.4. Renal binding sites were examined in detail, and shown to have affinity characteristics appropriate for mineralocorticoid receptors (aldosterone〉deoxycorticosterone〉dexamethasone〉cortisol〉progesterone〉oestradiol 〉 dihydrotestosterone).5. No difference in mineralocorticoid receptor affinity or concentration could be shown between Na+ replete and Na+ deplete sheep, in either kidney or parotid gland.6. Accordingly, the molecular mechanisms whereby parotid sensitivity is mediated remain as yet undefined.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1976.tb00637.x
