Electronic Resource
Hamet, P.
;
Sun, Y. L.
;
Malo, D.
;
[et al.]
Kong, D.
;
Křen, V.
;
Pravenec, M.
;
Kuneš, J.
;
Dumas, P.
;
Richard, L.
;
Gagnon, F.
;
Tremblay, J.
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental pharmacology and physiology
21 (1994), S. 0
ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. A significant portion of blood pressure variance is modified by the environment.2. The present report summarizes evidence that: (i) the environmental response is genetically determined; (ii) various stressors can evoke a differential response in hypertensive animals and constitute its intermediate phenotypes; (iii) the response to heat stress can be assigned to a single ‘thermosensitivity’ locus; (iv) candidate genes of susceptibility to environmental stresses are member(s) of the heat stress gene (HSP) gene families; (v) a restriction fragment length polymorphism ofhsp70 and a single base mutation in the 3′-untranslated region of hsp27 are associated with hypertension in recombinant inbred strains.3. In conclusion, HSP gene variants may be causative in susceptibility to hypertension.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1994.tb02464.x
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