Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental pharmacology and physiology
14 (1987), S. 0
ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
SUMMARY1. Sixteen stable asthmatics had the protective effects of inhaled fenoterol (200 μg) and inhaled ipratropium bromide (60 μg) against standardized histamine inhalation tests at 1 h examined in a randomized double blind fashion.2. There was no significant difference in the baseline forced expired volume in 1 s (FEV1) for the two study days (P 〉0.05).3. There was an increase in FEV, at 1 h on the fenoterol and ipratropium day compared with the fenoterol day (0.26 versus 0.17 1; P 〈 0.05).4. The geometric mean provocative concentration of histamine to cause a 20% fall in FEV, (PC20) was 6.31 mg/ml after fenoterol and 8.51 mg/ml after fenoterol and ipratropium (P= 0.038).5. There was no significant relationship between bronchodilator effect of the bronchodilators and the increase in PC20 from pre-study values, r= 0.307 (P=0.25) for fenoterol alone and r=0.195 (P=0.47) for fenoterol and ipratropium.6. The relationship between pre-study histamine responsiveness and the increase in PC20 caused by the bronchodilators just failed to reach statistical significance, r= -0.441 (P= 0.09) for fenoterol alone and r= -0.47 (P=0.06) for fenoterol and ipratropium.7. The study has shown a greater right shift of histamine responsiveness for combined inhaled fenoterol and ipratropium compared with inhaled fenoterol alone in this group of asthmatics.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1987.tb00961.x
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