Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental dermatology
19 (1994), S. 0
ISSN:
1365-2230
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Whether griseofuilvin, which pioneered oral antifungal therapy, works topically has long been an open question. The effectiveness of a 1% griseofulvin spray formulation and the vehicle alone against experimentally induced Trichophyton mentagrphytes lesions on the forearms of 16 healthy volunteers and in the treatment of 100 tinea pedis patients (various dermatophytes) was evaluated in a double-blind study. After treatment of teh58 induced lesions twice daily for 14 days with topical griseofulvin (28) of placebo(30),80% of lesions receiving griseofulvin were mycologically negative compared with 30% in the placebo group (p〈0.001), In the tinea pedis patients who applied medication once daily for 4 week and 80.9% 2 weeks post-treatment. Resurgence of dermatophytes quickly followed the end of treatment in the placebo group only, which had a mycological cure rate of 34%(week6) Administration of a ropical formulation of griseofulvin thus may be an effective treatment for interdigital dermatophyte infections.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2230.1994.tb01113.x
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