Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
British journal of dermatology
93 (1975), S. 0
ISSN:
1365-2133
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
A deficiency of epidermal cyclic adenosine 3′, 5′-monophosphate (cyclic AMP) has been implicated as the cause of the incomplete differentiation, increased mitosis and increased glycogen concentration which characterize the psoriatic lesion. This communication contains our data on the epidermal concentration of cyclic AMP in the lesional and ‘normal’ (non-involved) skin of patients with psoriasis. In these studies we have introduced the following improvement in methodology: (1) Local ischaemia in the biopsy specimens was prevented by not giving any injections prior to removal of the tissues and by freezing the tissues prior to removal. (2) The epidermis was microdissected from the dermis prior to cyclic AMP assay so as to give as pure an epidermal specimen as possible.Epidermal cyclic AMP was found to be 20–25% higher in the skin lesion than in the uninvolved skin when compared on a dry weight or protein basis but essentially the same when compared on the basis of DNA content. Our conclusion is that the cyclic AMP level in the psoriatic lesion is not lower than that in the ‘normal’ skin and thus these characteristics in psoriatic lesions cannot be related simply to a cyclic AMP deficiency.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2133.1975.tb06490.x
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