Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
British journal of dermatology
80 (1968), S. 0
ISSN:
1365-2133
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
SUMMARY. Photosensitization of the skin by demethylchlortetracycline and sulphanilamide has been demonstrated in mice.Demethylchlortetracycline has an action spectrum extending from 350 to 420 nm with a peak at 400 nm; it is most effective in mice when given by the intradermal route, less effective intraperitoneally and without action orally.Sulphanilamide has a photosensitizing action spectrum from 375 to 400 nm, i.e. mostly in the visible spectrum, with less certain activity at 280–300 and 550–600 nm; it is effective intradermally and inactive orally. The majority of the photosensitizing effects of sulphanilamide must be due either to the alteration of its constitution in the skin, or to a metabolic change in the skin itself since sulphanilamide does not absorb visible light. Possible mechanisms are discussed and a speculative hypothesis is proposed that a local disturbance of porphyrin metabolism may be implicated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2133.1968.tb12326.x
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