ISSN:
1365-2044
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Following induction of epidural analgesia with 0.375% bupivacaine, 120 healthy parturients were randomly assigned in a double blind fashion to one of eight infusion groups. All received 8ml.h-1 of0.125% bupivacaine either alone (control group), or with alfentanil at 133, 266 or 400μg.h-1 (groups A1-A3) or with diamorphine at 133, 266, 400 or 533μg.h1 (groups D1-D4). Significantly longer top-up intervals were achieved with the two highest doses of both alfentanil and diamorphine when compared with bupivacaine alone (p〈0.01), making the minimum effective doses 266 μg.h-1 of alfentanil and 400 ng.h-1 of diamorphine. Perineal analgesia was better in all the opioid groups compared with the control group (p 〈 0.05). The intensity of motor block was greater in the control group (p 〈 0.05). The incidence of pruritus did not differ between groups. The highest dose of diamorphine caused significantly more nausea. No significant neonatal side-effects were demonstrated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2044.1995.tb05996.x
