Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of periodontal research
20 (1985), S. 0
ISSN:
1600-0765
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Cathepsin D, cathepsin L, and cathepsin B activities were detected in homogenates of human gingival tissue from 20 patients with different degrees of periodontal disease and in one patient with juvenile periodontitis. Clinical plaque index (PI), gingival index (GI), and pocket depth were determined. Patients were divided into three groups with regard to the severity of the disease. Averaged values for the activities of all three lysosomal proteinases increased from the group with less damaged tissue to the group with more advanced periodontal disease. When the correlations between the specific activities of the cathepsins and pocket depth in each of 20 patients were considered by the linear regression analysis, the correlation coefficient for cathepsin D was much higher than for the other two cysteine proteinases. Cathepsin D was also extracted from the homogenates by specific immuno-adsorbtion on anticathepsin - D antibody - Sepharose and quantitatively determined; the average amount of enzyme ranged from 118.5 to 184.5 μg per mg of total protein extracted from the tissues and was positively correlated to pocket depths.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0765.1985.tb00828.x
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