ISSN:
1600-0765
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The flora of periodontal pockets 〈 6 mm and the rate of alveolar bone loss of one diseased site in each of eighteen adult beagle dogs were compared during a 6 month pretreatment period and a subsequent 12 month tetracycline treatment period. The dogs were divided into the following three groups and treated as follows: untreated controls (5), 250 mg tetracycline daily (5), and 500 mg tetracycline daily (7). An attempt was made to correlate the flora in deep periodontal pockets and the subsequent rate of alveolar bone loss in untreated control beagles and beagles treated with tetracycline (250 mg per day and 500 mg per day). The bacterial flora and the rate of bone loss of one site in each dog was compared during a six-month pretreatment period and a subsequent twelve-month tetracycline treatment period. The cultivable flora was classified according to cellular morphology. Gram stain, and atmospheric tolerance.The periodontal pocket flora was predominantly a Gram negative anaerobic flora at all time periods throughout the study. The flora of the untreated control dogs spontaneously shifted to a more Gram negative flora at 18 months of the study. In the treated dogs, after six months of tetracycline treatment, there was a significant shift to a more Gram negative flora which returned to baseline proportions after twelve months of treatment. A decrease in the numbers of bacteria sensitive in vitro to tetracycline was found in the course of the treatment period. No significant relationship was found between the cultivable flora of a specific site and the rate of alveolar bone loss for that site.The data suggest that in advanced periodontal disease in the beagle dogs studied a Gram negative anaerobic flora was predominantly cultivated. Broad groupings of bacteria cultivated from each site did not correlate with the rate of alveolar bone loss of each site.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0765.1981.tb01005.x
