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Digitale Medien

Uptake of L-[14C]Proline by Isolated Rat Brain Capillaries (1983)

Hwang, Shing Mei ; Miller, Michael ; Segal, Stanton

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 40 (1983), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: Rat brain capillaries exhibit concentrative uptake of l-proline. The uptake is mediated by two saturable systems, one with a Km of 0.11 mM and another with a Km of 5.9 mM. Entry also occurred by diffusion, especially at high substrate concentrations. The saturable high-affinity system is sodium-dependent, with a Km for sodium of 36 mM. Proline uptake is not inhibited by lysine, but is inhibited by phenylalanine, glycine and leucine. α-Methylaminoisobutyric acid (MeAIB), a model for sodium-requiring transport systems, is a competitive inhibitor of the low-Km system. b-2-Aminobicyclo-[2, 2, 1]-heptane-2-carboxylic acid (BCH), a model for nonsodium-dependent transport, however, also inhibited proline uptake.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1983.tb11285.x

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