Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
36 (1981), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract: The accumulation of the polyamine spermine into 0.1-mm prisms of rat cerebral cortex has been investigated at both 37°C and at 4°C. Kinetic analysis of the temperature-sensitive portion of uptake indicates two high-aftinity saturable components together with an unsaturable component at high concentrations. The ‘very high’– affinity saturable system (Km= 3.8 nM) was temperature- and sodium-dependent, and significantly reduced by metabolic inhibitors, findings that are consistent with an active transport system for spermine into brain tissue. The ‘high’– affinity saturable component (Km= 0.44 μM) was sodium-dependent and inhibited by ouabain, but only partially susceptible to inhibition by 2,4-dinitrophenol and sodium cyanide. The significance of these results with respect to the function of spermine in the central nervous system is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1981.tb00409.x
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