Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
19 (1972), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The removal of circulating ketone bodies by the brain was investigated in 0- to 8-day-old puppies under pentobarbital anaesthesia. Of the arterial acetoacetate (AcAc) and β-hydroxybutyrate (βOHB), 24 and 30 per cent, respectively, were removed by the brain. There was a direct correlation between the arterial concentrations of either AcAc or βOHB and the A-V difference of the respective ketone body across the brain. When a continuous infusion of Na-dl-3-hydroxybutyrate [3-14T] was administered for more than 2 h, labelling of both phospholipids and free cholesterol was consistently observed in all six areas of the brain that were sampled. We conclude that the removal and utilization of ketones is of physiological importance in the brain of newborn animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1972.tb05125.x
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