Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
16 (1969), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract— Slices of cerebral cortex were incubated in medium containing 0·75 or 2·8 mM 45CaCl2, in the presence or absence of 0·01–0·1 mm-ouabain. Ouabain induced accumulation of calcium by slices to a maximum of 4 μmoles/g of tissue/hr (0·75 mm-CaCl2 in the medium) and to 8 μmoles/g of tissue/hr (2·8 mm-CaCl2 in the medium). Accumulation of Ca2+ occurred more slowly than loss of K+ from the slices and more closely resembled the pattern of Na+ uptake.Mitochondrial fractions isolated from ouabain-treated slices contained significantly more calcium than controls. Inclusion of EDTA in the homogenization medium resulted in decreased amounts of particulate-bound calcium.The effect of ouabain on accumulation of calcium is discussed with regard to possible relationships to processes of active and passive transport.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1969.tb10354.x
| Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |
