Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of clinical periodontology
19 (1992), S. 0
ISSN:
1600-051X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract Cyclosporin is a selective immunosuppressant that has a variety of applications in medical practice. Like phenytoin and the calcium channel blockers, the drug is associated with gingival overgrowth. This review considers the pharmacokinetics, pharmacodynamics, uses and unwanted effects of Cyclosporin, in particular the action of the drug on the gingival tissues. Clinical and cell culture studies suggest that the mechanism of gingival overgrowth is a result of an interaction between the drug and its metabolites with susceptible gingival fibro-blasts. Plaque-induced gingival inflammation appears to enhance this interaction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-051X.1992.tb01140.x
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