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Structural Studies of Induced Antibodies with Defined Idiotypic Specificities (1976)

KLAPPER, D. G. ; STANKUS, R. P. ; LESLIE, G. A. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of immunology 5 (1976), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: The heavy (H) chains of three anti-streptococcal group A carbohydrate antibodies (anti-SACHO) of restricted heterogeneity, elicited in inbred Sprague-Dawley rats, were subjected to 40 cycles of automated Edman degradation. All three antibody H-chain preparations had an identical amino acid sequence and were classified as a variant of the VHIII subgroup of immunoglobulin H chains. A comparison of the H-chain sequence of these antibodies with that of pooled rat gamma chains suggests that a very minor population of H chains (closely related to the VHIII subgroup) has been ‘recruited’ as a consequence of this immunization. This observation further supports the notion that ‘framework’ and ‘specificity’ or “hypervariable regions” are closely linked.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-3083.1976.tb03043.x

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