ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
An anligen-specific T-cell line which transforms into T-lymphoma cells in vitro but apparently not in vivo is described. Membrane markers, tumorigenicity and T-cell receptor(TcR) Vα and Vβ- gene usage of the in vitro transformed T-cell line were analysed to investigate whether the transformation event was poly-, oligo-, or monoclonal. The results indicate that the Tlymphoma has no chromosome abnormalities, contains no tumour-inducing virus, can induee clone-specific immunity, and is oligodonal wilh respect to TcR Vα and Vβ expression. The nature of the transformation event and clinical application of vaccination against Tlymphomas is diseussed. In addition, the expressed TcR Vα and Vβ repertoire of Con A T blasts was apparently not affected by the Igh-I or the MHC haplotype, as investigated in lgh-1 and MHC congeneic C57BI mice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1990.tb02815.x
