Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
19 (1984), S. 0
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The cellular response in the human skin tuberculin reaction was studied with immunohistochemical double-staining techniques in frozen sections of skin biopsies taken 6 h to 8 days after intradermal PPD injections. Cell infiltrates were observed from day 2 onwards and increased in size up to 4 days. Most of the infiltrating cells reacted with anti-Leu 3a (T ‘helper/inducer’ phenotype) antibodies. In contrast to normal epidermis, not only Langerhans cells but also keratinocytes expressed MLA-DR antigens from day 4 onwards. The induction of HLA-DR antigens on keratinocytes may be secondary to T-cell activation. Since the HLA-DR expression on keratinocytes appeared late in the tuberculin reaction, the function may be to suppress rather than enhance the immune response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1984.tb00910.x
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