ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Human peripheral T-cell subpopulations revealed by monoclonal antibodies by means of a rescuing method were isolated by micromanipulation and submitted to electron microscopic analysis. The T3+ subset (total T cells) displayed a high degree of heterogeneity, including multiple transitional forms, from cells with a high nuclear to cytoplasmic ratio and rare organdies in cells with a low nuclear to cytoplasmie ratio and a complex system of cytoplusmic organdies. T4+ (inducer/helper) and T8+ (suppressor/cytotoxic) cell suhpopulations were shown to have no evident distinguishing characteristics. They both displayed the same morphological variation mentioned for T8+ lymphocytes. On morphometric analysis, these two cell subsets were very similar, with only slight differences for cell surface roughness, volume of mitochondria, extent of nuclear indentation, and surface area of the rough endoplasmic reticulum. The significance of these minor morphological differences is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1984.tb00913.x
