ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Murine splenic cells were separated on Ig-anti-Ig columns to yield cell populations depleted of IgM-FcR (Fc receptor)-expressing (Tm−) and IgG-FcR-expressing (Tg−) cells and also cells expressing neither of these two FcR (To). The proliferative response to the lectin concanavalin A (Con A) was shown to be present mainly in cell populations depleted of Tm cells (T cells lacking IgM FcR)—that is. Tm− and To. The low Con A response in the other cell populations, namely Tg− and Ttot, was due to a selection against T-cell growth factor (TCGF)-reactive cells, since TCGF production within these subsets was not impaired and the low proliferative response was not reconstituted by preformed TCGF. Tg− cells were able to inhibit the Con-A-induced proliferation of To and Tm− cells dose-dependently. These data strongly suggest the presence of a step-one regulatory, suppressive mechanism comprised within the Tm population.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1983.tb00800.x
